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A multi-omics approach to delineate sputum microbiome-associated asthma inflammatory phenotypes

Abdel-Aziz, Mahmoud I. (author)
Dept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands; Dept of Clinical Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Vijverberg, Susanne J.H. (author)
Dept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Neerincx, Anne H. (author)
Dept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
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Brinkman, Paul (author)
Dept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Wagener, Ariane H. (author)
Dept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Riley, John H. (author)
Respiratory Therapeutic Unit, GlaxoSmithKline, Stockley Park, United Kingdom
Sousa, Ana R. (author)
Respiratory Therapeutic Unit, GlaxoSmithKline, Stockley Park, United Kingdom
Bates, Stewart (author)
Respiratory Therapeutic Unit, GlaxoSmithKline, Stockley Park, United Kingdom
Wagers, Scott S. (author)
BioSci Consulting, Maasmechelen, Belgium
De Meulder, Bertrand (author)
European Institute for Systems Biology and Medicine, CIRI UMR5308, CNRS-ENS-UCBLINSERM, Lyon, France
Auffray, Charles (author)
European Institute for Systems Biology and Medicine, CIRI UMR5308, CNRS-ENS-UCBLINSERM, Lyon, France
Wheelock, Åsa M. (author)
Karolinska Institutet
Bansal, Aruna T. (author)
Acclarogen Ltd, St John’s Innovation Centre, Cambridge, United Kingdom
Caruso, Massimo (author)
Dept of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
Chanez, Pascal (author)
Département des Maladies Respiratoires APHM, U1067 INSERM, Aix Marseille Université Marseille, Marseille, France
Uddin, Mohib (author)
AstraZeneca BioPharmaceuticals R&D, Gothenburg, Sweden
Corfield, Julie (author)
AstraZeneca R&D, Molndal, Sweden; Areteva R&D, Nottingham, United Kingdom
Horvath, Ildiko (author)
Dept of Public Health, Semmelweis University, National Koranyi Institute for Pulmonology, Budapest, Hungary
Krug, Norbert (author)
Fraunhofer Institute for Toxicology and Experimental Medicine Hannover, Hannover, Germany
Musial, Jacek (author)
Dept of Medicine, Jagiellonian University Medical College, Krakow, Poland
Sun, Kai (author)
Data Science Institute, South Kensington Campus, Imperial College London, London, United Kingdom
Shaw, Dominick E. (author)
Respiratory Research Unit, University of Nottingham, Nottingham, United Kingdom
Sandström, Thomas, 1957- (author)
Umeå universitet,Avdelningen för medicin
Montuschi, Paolo (author)
Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy
Fowler, Stephen J. (author)
Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre and NIHR Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom
Lutter, René (author)
Dept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands; Dept of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Djukanovic, Ratko (author)
NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences, and Human Development and Health, University of Southampton, Southampton, United Kingdom
Howarth, Peter (author)
NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences, and Human Development and Health, University of Southampton, Southampton, United Kingdom
Skipp, Paul (author)
Centre for Proteomic Research, Biological Sciences, University of Southampton, Southampton, United Kingdom
Sanak, Marek (author)
Dept of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland
Adcock, Ian M. (author)
National Heart and Lung Institute, Imperial College London, Royal Brompton and Harefield NHS Trust, London, United Kingdom
Chung, Kian Fan (author)
National Heart and Lung Institute, Imperial College London, Royal Brompton and Harefield NHS Trust, London, United Kingdom
Sterk, Peter J. (author)
Dept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
Kraneveld, Aletta D. (author)
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands
Maitland-Van der Zee, Anke H. (author)
Dept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands; Dept of Pediatric Respiratory Medicine, Emma Children’s Hospital, Amsterdam UMC, Amsterdam, Netherlands
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 (creator_code:org_t)
2021-11-25
2022
English.
In: European Respiratory Journal. - : European Respiratory Society. - 0903-1936 .- 1399-3003. ; 59:1
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • A multi-omics approach revealed the underlying biological pathways in the microbiome-driven severe asthma phenotypes. This may help to elucidate new leads for treatment development, particularly for the therapeutically challenging neutrophilic asthma.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

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